Paul (Faulkner), who goes from the most infamous persecutor of Christians to Christ's most influential apostle, is spending his last days in a dark and bleak prison cell awaiting execution by Emperor Nero.
Luke (Caviezel), his friend and physician, risks his life when he ventures into Rome to visit him. Paul is under the watchful eye of Mauritius (Martinez), the prisons prefect, who seeks to understand how this broken old man can pose such a threat.
But before Paul's death sentence can be enacted, Luke resolves to write another book, one that details the beginnings of "The Way" and the birth of what will come to be known as the church. Their faith challenged an empire. But their words changed the world.